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KMID : 0859320060240040263
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Journal of the Korean Society for Therapeutic Radiology and Oncology
2006 Volume.24 No. 4 p.263 ~ p.271
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Effectiveness of Fentanyl Transdermal Patch (Fentanyl-TTS, Durogegicⓡ) for Radiotherapy Induced Pain and Cancer Pain: Multi-center Trial
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Shin Seong-Soo
Shin Hyun-Soo
Huh Seung-Jae
Choi Eun-Kyung
Kim Jong-Hoon
Ahn Seung-Do
Lee Sang-wook
Kim Yeon-Sil
Lee Kyu-Chan
Lee Chang-Geol
Loh John-JK
Chun Mi-Son
Oh Young-Teak
Kim Ok-Bae
Kim Jin-Hee
Kim Chul-Yong
Yang Dae-Sik
Park Woo-Yoon
Kim Bo-Kyoung
Cho Heung-Lae
Ahn Ki-Jung
Lee Jong-Young
Youn Seon-Min
Ahn Yong-Chan
Lim Do-Hoon
Park Won
Kang Ki-Moon
Wu Hong-Gyun
Jang Seong-Soon
Kim Eun-Seog
Kim Yong-Ho
Nah-Byung-Sik
Chung Woong-Ki
Nam Taek-Keun
Ahn Sung-Ja
Song MI-Hee
Yun Sang-Mo
Kay Chul-Seung
Yei Ji-won
Park Suk-Won
Kim Seon-Woo
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Abstract
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Purpose: To evaluate the effectiveness and safety of fentanyl-TTS in the management of radiotherapy induced
acute pain and cancer pain treated with radiotherapy.
Materials and Methods: Our study was open labelled prospective phase IV multi-center study. the study
population included patients with more 4 numeric rating scale(NRS) score pain although managed with other
analgesics or more than 6 NRS score pain without analgesics. Patients divided into two groups; patients with
radiotherapy induced pain (Group A) and patients with cancer pain treated with radiotherapy (Group B). All
patients received 25 ug/hr of fentanyl transdermal patch. Primary end point was pain relief; second end points
were change in patient quality of life, a degree of satisfaction for patients and clinician, side effects.
Results: Between March 2005 and June 2005, 312 patients from 26 participating institutes were registered, but
249 patients completed this study. Total number of patients in each group was 185 in Group A, 64 in Group
B. Mean age was 60 years and male to female ratio was 76:24. Severe pain NRS score at 2 weeks after the
application of fentanyl was decreased from 7.03 to 4.01, p=0.003. There was a significant improvement in
insomnia, social functioning, and quality of life. A degree of satisfaction for patients and clinician was very high.
The most common reasons of patients’ satisfactions was good pain control. Ninety six patients reported side
effect. Nausea was the most common side effect. There was no serious side effect.
Conclusion: Fentanyl-TTS was effective in both relieving pain with good tolerability and improving the quality
of life for patients with radiotherapy induced acute pain and cancer pain treated with radiotherapy. The
satisfaction of the patients and doctors was good. There was no major side effect.
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KEYWORD
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Cancer pain, Radiotherapy induced pain, Fentanyl Transdermal Patch
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